LESION FOLLOWUP / OFFLINE REVIEW

Every change.
Its reference. Its evidence.

An ordered review of manually measured CT target lesions.

RECIST 1.1 · TARGET SUBSET

synthetic-target-followup

Baseline 2026-01-01
ct-venous-5mm · 5.0 mm slices

Target categories are one component of response review. Non-target disease, new lesions, confirmation and overall response are outside this report.

Target burden over time

Complete comparable visits define the trend; NE visits leave a gap.

DIAMETER SUM / mm

CRPRSDPDNE / line break

Visit ledger

Baseline is the PR reference. The prior minimum is the PD reference.

Visit	Target category	Sum / mm	vs baseline	Prior nadir / mm	Nadir visit	vs nadir
week-2 2026-01-15	PR	35.0	-30.00%	50.0	baseline	-30.00%
week-4 2026-02-01	PR	20.0	-60.00%	35.0	week-2	-42.85%
week-6 2026-02-15	PR	24.0	-52.00%	20.0	week-4	+20.00%
week-8 2026-03-01	PD	25.0	-50.00%	20.0	week-4	+25.00%

Measurement evidence

Open a visit to review target observations and the exact rule path.

PRweek-22026-01-15

Target	Axis	Observation	Baseline / mm	Effective / mm
T1	Longest diameter	measured	30.0	20.0
N1	Node short axis	measured	20.0	15.0

Exact calculation conditions

Diameter components / mm: T1=20.0 + N1=15.0 → S=35.0; B=50.0; N=50.0 (baseline). S=current sum; B=baseline; N=prior eligible minimum. Comparisons below use 0.1 mm integers and integer cross-products. Inactive criteria are skipped by an earlier gate. Findings explain NE and history gates.

Criterion / target	Integer comparison	Result / use
Complete measurements `complete_measurements`	1 == 1	true / active
Matching technique ID `comparable_technique`	1 == 1	true / active
History gate open `context_open`	1 == 1	true / active
Non-nodal CR: 0.0 mm `non_nodal_cr` T1	200 == 0	false / active
Node CR: short axis below 10.0 mm `node_cr_short_axis` N1	150 < 100	false / active
PD relative growth: 5S >= 6N `pd_relative_5S_ge_6N`	1750 >= 3000	false / active
PD absolute increase: at least 5.0 mm `pd_absolute_S_minus_N_ge_50`	-150 >= 50	false / active
PR from baseline: 10S <= 7B `pr_10S_le_7B`	3500 <= 3500	true / active

target_pr

Diameter sum decreased at least 30% from baseline; PD criteria do not apply.

PRweek-42026-02-01

Target	Axis	Observation	Baseline / mm	Effective / mm
T1	Longest diameter	measured	30.0	10.0
N1	Node short axis	measured	20.0	10.0

Exact calculation conditions

Diameter components / mm: T1=10.0 + N1=10.0 → S=20.0; B=50.0; N=35.0 (week-2). S=current sum; B=baseline; N=prior eligible minimum. Comparisons below use 0.1 mm integers and integer cross-products. Inactive criteria are skipped by an earlier gate. Findings explain NE and history gates.

Criterion / target	Integer comparison	Result / use
Complete measurements `complete_measurements`	1 == 1	true / active
Matching technique ID `comparable_technique`	1 == 1	true / active
History gate open `context_open`	1 == 1	true / active
Non-nodal CR: 0.0 mm `non_nodal_cr` T1	100 == 0	false / active
Node CR: short axis below 10.0 mm `node_cr_short_axis` N1	100 < 100	false / active
PD relative growth: 5S >= 6N `pd_relative_5S_ge_6N`	1000 >= 2100	false / active
PD absolute increase: at least 5.0 mm `pd_absolute_S_minus_N_ge_50`	-150 >= 50	false / active
PR from baseline: 10S <= 7B `pr_10S_le_7B`	2000 <= 3500	true / active

target_pr

Diameter sum decreased at least 30% from baseline; PD criteria do not apply.

PRweek-62026-02-15

Target	Axis	Observation	Baseline / mm	Effective / mm
T1	Longest diameter	measured	30.0	14.0
N1	Node short axis	measured	20.0	10.0

Exact calculation conditions

Diameter components / mm: T1=14.0 + N1=10.0 → S=24.0; B=50.0; N=20.0 (week-4). S=current sum; B=baseline; N=prior eligible minimum. Comparisons below use 0.1 mm integers and integer cross-products. Inactive criteria are skipped by an earlier gate. Findings explain NE and history gates.

Criterion / target	Integer comparison	Result / use
Complete measurements `complete_measurements`	1 == 1	true / active
Matching technique ID `comparable_technique`	1 == 1	true / active
History gate open `context_open`	1 == 1	true / active
Non-nodal CR: 0.0 mm `non_nodal_cr` T1	140 == 0	false / active
Node CR: short axis below 10.0 mm `node_cr_short_axis` N1	100 < 100	false / active
PD relative growth: 5S >= 6N `pd_relative_5S_ge_6N`	1200 >= 1200	true / active
PD absolute increase: at least 5.0 mm `pd_absolute_S_minus_N_ge_50`	40 >= 50	false / active
PR from baseline: 10S <= 7B `pr_10S_le_7B`	2400 <= 3500	true / active

target_pr

Diameter sum decreased at least 30% from baseline; PD criteria do not apply.

PDweek-82026-03-01

Target	Axis	Observation	Baseline / mm	Effective / mm
T1	Longest diameter	measured	30.0	15.0
N1	Node short axis	measured	20.0	10.0

Exact calculation conditions

Diameter components / mm: T1=15.0 + N1=10.0 → S=25.0; B=50.0; N=20.0 (week-4). S=current sum; B=baseline; N=prior eligible minimum. Comparisons below use 0.1 mm integers and integer cross-products. Inactive criteria are skipped by an earlier gate. Findings explain NE and history gates.

Criterion / target	Integer comparison	Result / use
Complete measurements `complete_measurements`	1 == 1	true / active
Matching technique ID `comparable_technique`	1 == 1	true / active
History gate open `context_open`	1 == 1	true / active
Non-nodal CR: 0.0 mm `non_nodal_cr` T1	150 == 0	false / active
Node CR: short axis below 10.0 mm `node_cr_short_axis` N1	100 < 100	false / active
PD relative growth: 5S >= 6N `pd_relative_5S_ge_6N`	1250 >= 1200	true / active
PD absolute increase: at least 5.0 mm `pd_absolute_S_minus_N_ge_50`	50 >= 50	true / active
PR from baseline: 10S <= 7B `pr_10S_le_7B`	2500 <= 3500	true / inactive

target_pd

Diameter sum increased at least 20% and at least 5.0 mm from the prior nadir.

Individual target trends

Each target uses its own vertical scale. V1, V2 follow the visit ledger. Squares mark the explicit 5.0 mm default; crosses have no diameter. Hollow points retain an observation from an NE visit. Connecting lines stop at NE or missing visits. These points do not make an NE visit eligible for the total trend or nadir.

Visit / date	Target / axis	Observation	Effective / mm	Visit target category
Baseline 2026-01-01	T1 · Longest diameter	baseline measurement	30.0	—
Baseline 2026-01-01	N1 · Node short axis	baseline measurement	20.0	—
week-2 2026-01-15	T1 · Longest diameter	measured	20.0	PR
week-2 2026-01-15	N1 · Node short axis	measured	15.0	PR
week-4 2026-02-01	T1 · Longest diameter	measured	10.0	PR
week-4 2026-02-01	N1 · Node short axis	measured	10.0	PR
week-6 2026-02-15	T1 · Longest diameter	measured	14.0	PR
week-6 2026-02-15	N1 · Node short axis	measured	10.0	PR
week-8 2026-03-01	T1 · Longest diameter	measured	15.0	PD
week-8 2026-03-01	N1 · Node short axis	measured	10.0	PD

Fixed baseline target set

Target	Organ group	Kind	Baseline / mm
T1	liver	Longest diameter	30.0
N1	lymph_nodes	Node short axis	20.0

Terms

Target-only terms: CR complete response; PR partial response; SD stable disease; PD progressive disease; NE not evaluable. Baseline is the initial target sum; prior nadir is the lowest earlier eligible sum. n/a means unavailable, never zero.